HI PP. There’s quite a lot from Bridle and Malone, especially the latter, and having dug around a bit/lot I don’t think it can be said that they are not joining the dots.
In the Alex Pierson interview Bridle did say the SP was toxic: " “We made a big mistake. We didn’t realize it until now,” said Byram Bridle, a viral immunologist and associate professor at University of Guelph, Ontario. “We thought the spike protein was a great target antigen, we never knew the spike protein itself was a toxin and was a pathogenic protein. So by vaccinating people we are inadvertently inoculating them with a toxin.”
Whether he has written that I’m not sure. There may be a reluctance among top experts to be the one that ends up as the first public slayer of the experimental vaccine project.
I’ll leave Bridle there and concentrate on Malone’s statements.
Malone is clear that he thinks the SP is dangerous. This emerged in the June 21, Dark Horse project video, which I’m sure I saw here first but can’t locate now.
We’ve only scratched the surface of this very long discussion. Here is a (poor) transcript:
(Link https://drive.google.com/file/d/1QrXpEJgIJMdEDbwGYeQxRkws2f1qQVcY/view)
Here are some parts relevant to the discussion:
…
Speaker 2 (Weinstein): The other problem, and this is your area of expertise, is that what the what these vaccines do is they encode spike protein alone so that the immune system will learn to recognize by protein and will catch it quickly when one is confronted with covid. But the spike protein itself, we now know, is very dangerous and cytotoxic. Is that a fair description?
Speaker3 (Malone): More than fair. And I alerted the FDA about this risk months and months and months ago.
About 6m.
Kersh: To be fair the FDA knew about the vaccine distribution but they didn’t know the SP was toxic
Malone: They did know. I did send them manuscripts. They didn’t think that was sufficient documentation of the risk that the spike was biologically active.
Weinstein: We now know SP is very dangerous. (Malone may accord, unfortunately drowned out by Kersh)
…
Malone: it’s not just the vaccine documentation there was also the prior literature that was put out by the people that developed it, these clones. They were aware there was a risk of spike being biologically active and having adverse events if it did not stay stuck to the cells that were transfected that got the RNA and made it - okay? and they used a genetic engineering method of putting a transmembrane domain on it to ensure that it stayed anchored and stayed put. And there they did limited non-clinical studies to say looks like it stays stuck, right? we engineered it to stay stuck and they published that.
Here’s the thing - “specially engineered, okay?”. Um, that’s generally not good enough in a non-clinical data package. So before we get a product released in humans, in the normal situation where we are not in a rush, we have some really rigorous tests that need to be done in animals. And revealing that spike gets cleaved off of expressed cells and becomes free is something that absolutely should have been known and understood well before this ever got known and put into humans, so I’ll just leave it at that-
OK back to ME rambling…
So at the very least according to Malone, an absolutely pro-vaccine expert,
- there is a real risk that wasn’t supposed to exist, and
- one that should absolutely have been analysed before vaccines were rolled out.
Soon afterwards he raises another risk:
Malone: "the whole reason to use an adenoviral vector or mRNA is not just to generate antibodies, and a lot of this data and a lot of us who are deep into this data think that the way that they’re really providing the protection is by cellular cytotoxicity. So you’re getting CTLs {Cytotoxic T-lymphocyte}against it and that the reason to use this gene-therapy-based technology is not just to generate neutralizing antibodies but to generate cytotoxicity lymphocytes. "
This may be the most pertinent comment. As I understand it, if the cells that get the mRNA are destroyed, you don’t want that to be happening in the wrong place.
The cytotoxicity is not an accident, it arises, if I’ve read it right, from the function of the vaccine spike - to attract the ire of the immune system to kill the infected cells.
This has been a point of discussion between experts and interested medics for some time. This is an excerpt of an article from the online publication Microbial Instincts (link at bottom).
It can be seen that it refers to a discussion in the online BMJ of March 2021:
"As a result, brain cells that express the spike protein might be marked as foreign by the immune system. For example, cytotoxic T-cells, which kill virus-infected and cancerous cells, might see the spike protein-expressing brain cells as a threat. Unlike muscle cells and many other cell types, neurons in the brain rarely regenerate.
Jacob Wes Ulm, MD, Ph.D., a geneticist, explained this concern in detail in a letter to the British Medical Journal, as well as in a public comment to an article about mRNA vaccines on January 2021:
…it seems that they [mRNA vaccines] can enter a much broader tissue range compared to even attenuated virus vaccines…And since the mRNA vaccines would induce SARS-CoV-2 viral spike protein expression, that seems to mean that people who get the mRNA vaccines are going to have a much greater range of cells and tissues vulnerable to cytotoxic [T-cell] attack…with side effects that may not manifest for years (with cumulative damage and chronic inflammation).
“This is where the picture gets aggravatingly murky,” Dr. Ulm added, mentioning that there seems to be no comprehensive data on the cellular localization — i.e., which types of cells the biomaterial enters— of the LNPs used by Pfizer-BioNTech and Moderna.
Although there have been past studies(Link: Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes - ScienceDirect) on the cellular localization of LNPs (more on this below), different LNP formulations would enter different cell types, Dr. Ulm stated, so “we don’t know where in the body they’re going,” adding that:
The nightmare scenario would be if e.g. the mRNA vaccines’ lipid nanoparticles are, indeed, crossing the BBB and getting endocytosed into critical glial cells, like oligodendrocytes, or even worse, into neurons themselves in the brain and spinal cord, putting a bullseye on these critical cells for cytotoxic [T-cells]."
The writer in Microbial Instincts is trying to strike a balance, and goes on to give reasons why it might not be a problem.
It’s worth noting that in the biodistribution study, the lipids reached the brain.
Going back to Dark Horse, the three speakers clearly discuss what sorts of diseases might follow from unwanted spike protein activity (which might just be getting cells killed!?).
"Weinstein: I think we need to look for leukemias, because of their creation in bone marrow. I know from other work that it also seems to show up preferentially in lymph nodes which raises the question of whether lymphomas might be created. These are possible long term effects, we have no way of knowing don’t arise because these things have not been injected into people for more than a year.
Malone: So we have two types of events, my friends at the FDA tell me that are relevant to what you say, you’re focussing on bone marrow. Typically aplastic, anemia, leukemia, lymphoma those kinds of things…we might see it if there’s a signal. Could be six months, three years, nine years as it’s a progression of cancer that often needs multiple mutations. "
They also noted somewhere that platelets are made in the bone marrow, and are obviously implicated in the blood clots and related outcomes now attributed to the vaccine.
Malone also says " Another one that is very hard to understand that’s starting to come up in the database is reactivation of latent viruses. Shingles is an example of that. But there are many others and there’s something in the literature about reactivation of human latent human retroviruses."
ED again. I think Judy Mikowiks mentioned this last possibility?
They also discuss immune system effects.
"Speaker 2 (Weinstein): We’ve got potential long term. We got short term implications in the bone marrow. We’ve got potential long term implications in the bone marrow. We have short term implications in the ovaries. We’ve got potential long term implications. I would add to the list what I’ve been worried about most from the beginning are auto immune disorders that might show up in the long term. Is that Plausible?
Speaker3 (Malone): I we talked about this earlier on in for me, it’s less the lipid component, although that certainly has merit for auto immune. It’s more the circulating free spike protein, which we didn’t expect. And in the literature and we were … the developers assured us this would not happen. The literature suggested we would not have three (free?) spike and then Harvard and Brigham did a study in nurses. And lo and behold, we clearly have three (free) spike after vaccination. Yeah. And that has a whole other set of implications. But auto immune development of autoimmune disease against complexes of foreign protein plus normal human proteins is certainly something that you’d have to monitor for as we were discussing the way that that’s that’s part of the reason why you typically want a two to three year follow up period on the initial group of Phase three patients to make sure that autoimmune consequences don’t develop because they typically take time."
All-in-all there is a wide range of knock-on effects discussed, that are all possible and some seem to have emerged already…
There is much more in the discussion which is very revealing as it shows pro-vaccine experts dealing with emerging realities. The least expert, Kersh, said none of them were even against mRNA vaccines, it’s just this one because the spike protein (as Malone said) gets cleaved off and roams free.
(Link to Microbial Instincts article, FWIW: Concerns of Lipid Nanoparticle Carrying mRNA Vaccine into the Brain: What to Make of It? | by Shin Jie Yong | Microbial Instincts | Medium)
Cheers